N-(2-hydroxyethyl)-5-(methoxymethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:N-(2-hydroxyethyl)-5-(methoxymethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide
CAS No.:1313197-49-7
Molecular Formula:C₂₅H₂₄F₃N₃O₃S
Molecular Weight:503.545
Hs Code.:

Synonyms:N-(2-hydroxyethyl)-5-(methoxymethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

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Chemical Property of N-(2-hydroxyethyl)-5-(methoxymethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

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Technology Process of N-(2-hydroxyethyl)-5-(methoxymethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

There total 5 articles about N-(2-hydroxyethyl)-5-(methoxymethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₉F₃N₂O₃S

: 141-43-5
ethanolamine

: 1313197-49-7
N-(2-hydroxyethyl)-5-(methoxymethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Guidance literature:: C₂₃H₁₉F₃N₂O₃S; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 0.0833333h;

ethanolamine; In N,N-dimethyl-formamide;

Reference yield:

: 1207970-76-0
4,4,5,5-tetramethyl-2-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1,3,2-dioxaborolane

: 1313197-49-7
N-(2-hydroxyethyl)-5-(methoxymethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 6 h / 85 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 35 °C

4: sodium hydroxide; water / ethanol; tetrahydrofuran / 4 h / 85 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

With pyridine; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 4-ethoxycarbonyl-5-hydroxymethyl-3-methylpyrazole

: 1313197-49-7
N-(2-hydroxyethyl)-5-(methoxymethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 6 h / 85 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 35 °C

4: sodium hydroxide; water / ethanol; tetrahydrofuran / 4 h / 85 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

With pyridine; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;