Thiophene, 3,4-difluorotetrahydro-, 1,1-dioxide, (3R,4S)-rel- (9CI)

Base Information

• Chemical Name: Thiophene, 3,4-difluorotetrahydro-, 1,1-dioxide, (3R,4S)-rel- (9CI)
• CAS No.: 220704-95-0
• Molecular Formula: C4H6 F2 O2 S
• Molecular Weight: 156.153
• Mol file: 220704-95-0.mol

Synonyms:Thiophene, 3,4-difluorotetrahydro-, 1,1-dioxide, (3R,4S)-rel- (9CI)

Chemical Property of Thiophene, 3,4-difluorotetrahydro-, 1,1-dioxide, (3R,4S)-rel- (9CI)

Chemical Property:

• Boiling Point: 312.0±42.0 °C(Predicted)
• PSA: 42.52000
• Density: 1.44±0.1 g/cm3(Predicted)
• LogP: 1.17180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiophene, 3,4-difluorotetrahydro-, 1,1-dioxide, (3R,4S)-rel- (9CI)

There total 1 articles about Thiophene, 3,4-difluorotetrahydro-, 1,1-dioxide, (3R,4S)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

3-Sulfolene (77-79-2) → 3,4-epoxy-tetrahydro-thiophene-1,1-dioxide (4509-11-9) + 3-Fluoro-2,3-dihydrothiophene-1,1-dioxide (695-27-2) + trans-3,4-Difluoro-2,3,4,5-tetrahydrothiophene-1,1-dioxide (51237-22-0,132287-84-4) + cis-3,4-Difluoro-2,3,4,5-tetrahydrothiophene-1,1-dioxide (220704-95-0)

Guidance literature:

With water; fluorine; In acetonitrile; Ambient temperature;

DOI:10.1016/S0022-1139(98)00252-8

Reference yield:

cis-3,4-Difluoro-2,3,4,5-tetrahydrothiophene-1,1-dioxide (220704-95-0) → 3,4-Difluoro-4,5-dihydrothiophene-1,1-dioxide (220705-02-2) + cis-3-Chloro-3,4-difluoro-2,3,4,5-tetrahydrothiophene-1,1-dioxide + cis-3,4-Dichloro-3,4-difluoro-2,3,4,5-tetrahydrothiophene-1,1-dioxide + trans-3,4-Dichloro-3,4-difluoro-2,3,4,5-tetrahydrothiophene-1,1-dioxide

Guidance literature:

With chlorine; In tetrachloromethane; for 7h; Yield given; Yields of byproduct given; Irradiation;

DOI:10.1016/S0022-1139(98)00252-8

upstream raw materials:

3-Sulfolene

Downstream raw materials:

3,4-Difluoro-4,5-dihydrothiophene-1,1-dioxide