(2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine

Base Information

Chemical Name:(2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine
CAS No.:1373929-12-4
Molecular Formula:C₂₁H₂₉NO₆
Molecular Weight:391.464
Hs Code.:

Synonyms:(2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine

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Chemical Property of (2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine

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Technology Process of (2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine

There total 3 articles about (2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1035815-57-6
4-(benzyloxy)-2-methyl-3-oxobutanoic acid

: 190080-34-3
(2RS,5S)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine

: 1373929-12-4
(2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 5.5h; Inert atmosphere;
DOI:10.1039/c7ob01148b

Reference yield: 18.0%

: 93250-89-6,93250-90-9
methyl (2R,4S)-2-(tert-butyl)-1,3-oxazolane-4-carboxylate

: 214333-77-4
benzyl 4-(benzyloxy)-2-methyl-3-oxobutanoate

: 1373929-12-4
(2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 5.25h;
DOI:10.1039/c2ob00042c

Reference yield:

: 61795-51-5
benzyl 4-(benzyloxy)-3-oxobutanoate

: 1373929-12-4
(2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.67 h / 0 - 20 °C

1.2: 5 h

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5.25 h / 0 - 20 °C

With dmap; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2ob00042c