214333-77-4

Upstream product

• 31600-43-8 methyl 2-(benzyloxy)acetate 
• 122-63-4 benzyl proprionate 
• 61795-51-5 benzyl 4-(benzyloxy)-3-oxobutanoate 
• 74-88-4 methyl iodide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1373929-12-4 (2R,5S)-1-(4-(benzyloxy)-2-methyl-3-oxobutanoyl)-2-(tert-butyl)-5-methoxycarbonyl-1,3-oxazolidine 
• 1035815-57-6 4-(benzyloxy)-2-methyl-3-oxobutanoic acid 
• 1373929-21-5 (2R,5R,6S,7S)-1-aza-6-((benzyloxy)methyl)-2-(tert-butyl)-6-hydroxy-5-methoxycarbonyl-7-methyl-3-oxa-8-oxobicyclo[3.3.0]-octane 
• 1373929-18-0 (2R,5R,6S,7R)-1-aza-2-(tert-butyl)-6-hydroxy-7-methyl-6-(benzyloxymethyl)-5-methoxycarbonyl-3-oxa-8-oxobicyclo[3.3.0]octane 
• 1373929-15-7 (2R,5R,6R,7S)-1-aza-6-((benzyloxy)methyl)-2-(tert-butyl)-6-hydroxy-5-methoxycarbonyl-7-methyl-3-oxa-8-oxobicyclo[3.3.0]-octane 
• 1373929-25-9 (2R,3R,4S)-3-benzyloxymethyl-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxopyrrolidine-2-carboxylic acid methyl ester 
• 1373929-29-3 (2R,3R,4S)-3-((benzyloxy)methyl)-3-hydroxy-2-hydroxymethyl-4-methyl-5-oxopyrrolidine-2-carboxylic acid 
• 1373929-31-7 (2R,3R,4S)-2-acetoxymethyl-3-benzyloxymethyl-3-hydroxy-4-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 221103-65-7 4-Benzyloxy-2-{(2S,3S)-1-(tert-butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-methyl-3-oxo-butyric acid benzyl ester 
• 214333-83-2 (3S,4R)-4-((R)-3-Benzyloxy-1-methyl-2-oxo-propyl)-1-(tert-butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one 
• 214333-85-4 (3S,4R)-4-((R)-3-Benzyloxy-1-methyl-2-oxo-propyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one 

Relevant academic research and scientific papers

Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin

Biomimetic intramolecular aldol reactions on oxazolidine templates derived from serine may be used to generate densely functionalised pyroglutamates, which are simpler mimics of the right hand side of oxazolomycin. Some of the compounds from this sequence exhibit in vivo activity against S. aureus and E. coli, suggesting that pyroglutamate scaffolds may be useful templates for the development of novel antibacterials, and cheminformatic analysis has been used to provide some structure-activity data.

A stereoselective synthesis of a 2-functionalized-methyl-1β-methylcarbapenem key intermediate via decarboxylation

An efficient synthesis of a key intermediate 2a for the synthesis of 2-functionalized methyl-1β-methylcarbapenem antibiotics 1 has been realized via a stereoselective decarboxylation reaction.