Propanenitrile, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, (2S)- (9CI)

Base Information

• Chemical Name: Propanenitrile, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, (2S)- (9CI)
• CAS No.: 220666-10-4
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.197
• Mol file: 220666-10-4.mol

Synonyms:Propanenitrile, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, (2S)- (9CI)

Chemical Property of Propanenitrile, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, (2S)- (9CI)

Chemical Property:

• PSA: 42.25000
• LogP: 1.44168

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanenitrile, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, (2S)- (9CI)

There total 1 articles about Propanenitrile, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, (2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-dihydro-2H-pyran (110-87-2) + (-)-2-hydroxypropionitrile (87834-47-7) → (S)-2-(2-tetrahydropyranyloxy)propanenitrile (220666-10-4)

Guidance literature:

DOI:10.1246/bcsj.72.99

Reference yield:

1-Bromopentane (110-53-2) + (S)-2-(2-tetrahydropyranyloxy)propanenitrile (220666-10-4) → (+)-(2S)-2-hydroxyoctan-3-one (84435-13-2)

Guidance literature:

With hydrogenchloride; magnesium; Yield given; Multistep reaction; 1.) ether, 2.) ether, 0 deg C to room temperature, 2 h, 3.) room temperature, overnight;

DOI:10.1246/bcsj.72.99

Reference yield:

propyl bromide (106-94-5) + (S)-2-(2-tetrahydropyranyloxy)propanenitrile (220666-10-4) → (S)-2-hydroxyhexan-(3)-one (152519-33-0)

Guidance literature:

With hydrogenchloride; magnesium; Yield given; Multistep reaction; 1.) ether, 2.) ether, 0 deg C to room temperature, 2 h, 3.) room temperature, overnight;

DOI:10.1246/bcsj.72.99

upstream raw materials:

3,4-dihydro-2H-pyran

(-)-2-hydroxypropionitrile

Downstream raw materials:

(+)-(2S)-2-hydroxyoctan-3-one

(S)-2-hydroxyhexan-⁽³⁾-one