(S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

Base Information

Chemical Name:(S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
CAS No.:1276021-65-8
Molecular Formula:C₁₉H₂₀N₄O₂
Molecular Weight:336.393
Hs Code.:

Synonyms:(S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

Suppliers and Price of (S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 7 raw suppliers

Chemical Property of (S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

There total 17 articles about (S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.9%

: 1276021-71-6
C₂₆H₃₀N₄O₃

: 122-51-0
orthoformic acid triethyl ester

: 1276021-65-8
(S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

Guidance literature:: C₂₆H₃₀N₄O₃; orthoformic acid triethyl ester; for 0.5h; Reflux;

With trifluoroacetic acid; at 20 ℃; for 14h;

pH=7; Buffer;

Reference yield:

: 70080-54-5
4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester

: 1276021-65-8
(S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 13 steps

1.1: potassium carbonate / acetonitrile / 18 h / Reflux

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 18 h / Reflux

3.1: hydrogen; ammonia / Raney nickel / ethanol; methanol / 20 h / 4395.87 Torr

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

4.2: 0 °C

5.1: triethylamine / dichloromethane / 3 h / 20 °C

6.1: Chiralpak IA / ethyl acetate; hexane / Resolution of racemate

7.1: triethylamine / dichloromethane / 14 h / 0 - 20 °C

8.1: sodium azide / N,N-dimethyl-formamide / 2 h / 70 °C

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 14 h / 20 °C / 3000.3 Torr / Inert atmosphere

10.1: ethanol / 5 h / 20 °C

10.2: 14 h / 0 - 20 °C

11.1: trifluoroacetic acid / dichloromethane

11.2: 1 h / Reflux

12.1: cesium fluoride; rac-diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 95 °C / Inert atmosphere

13.1: 0.5 h / Reflux

13.2: 14 h / 20 °C

13.3: pH 7 / Buffer

With lithium aluminium tetrahydride; sodium azide; hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; potassium carbonate; rac-diaminocyclohexane; triethylamine; cesium fluoride; trifluoroacetic acid; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 108-95-2,27073-41-2
phenol

: 1276021-65-8
(S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 14 steps

1.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C

1.2: 15.5 h / 0 - 20 °C

1.3: Cooling

2.1: potassium carbonate / acetonitrile / 18 h / Reflux

3.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 18 h / Reflux

4.1: hydrogen; ammonia / Raney nickel / ethanol; methanol / 20 h / 4395.87 Torr

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

5.2: 0 °C

6.1: triethylamine / dichloromethane / 3 h / 20 °C

7.1: Chiralpak IA / ethyl acetate; hexane / Resolution of racemate

8.1: triethylamine / dichloromethane / 14 h / 0 - 20 °C

9.1: sodium azide / N,N-dimethyl-formamide / 2 h / 70 °C

10.1: hydrogen / palladium 10% on activated carbon / ethanol / 14 h / 20 °C / 3000.3 Torr / Inert atmosphere

11.1: ethanol / 5 h / 20 °C

11.2: 14 h / 0 - 20 °C

12.1: trifluoroacetic acid / dichloromethane

12.2: 1 h / Reflux

13.1: cesium fluoride; rac-diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 95 °C / Inert atmosphere

14.1: 0.5 h / Reflux

14.2: 14 h / 20 °C

14.3: pH 7 / Buffer

With aluminum (III) chloride; lithium aluminium tetrahydride; sodium azide; hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; potassium carbonate; rac-diaminocyclohexane; triethylamine; cesium fluoride; trifluoroacetic acid; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;