1-(3-Oxatricyclo[3.2.1.0~2,4~]octan-6-yl)methanamine

Base Information

• Chemical Name: 1-(3-Oxatricyclo[3.2.1.0~2,4~]octan-6-yl)methanamine
• CAS No.: 220555-34-0
• Molecular Formula: C₈H₁₃NO
• Molecular Weight: 139.197
• DSSTox Substance ID: DTXSID70569851
• Mol file: 220555-34-0.mol

Synonyms:220555-34-0;3-Oxatricyclo[3.2.1.02,4]octane-6-methanamine (9CI);1-(3-Oxatricyclo[3.2.1.0~2,4~]octan-6-yl)methanamine;DTXSID70569851;EN300-217481;(3-Oxatricyclo[3.2.1.02,4]octan-6-yl)methanamine;{3-oxatricyclo[3.2.1.0,2,4]octan-6-yl}methanamine;exo-5-aminomethyl-exo-2,3-epoxybicyclo[2.2.1]heptane

Chemical Property of 1-(3-Oxatricyclo[3.2.1.0~2,4~]octan-6-yl)methanamine

Chemical Property:

• PSA: 38.55000
• LogP: 1.06880
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 139.099714038
• Heavy Atom Count: 10
• Complexity: 171

Purity/Quality:

3-oxatricyclo[3.2.1.0,2,4]octan-6-ylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2CC(C1CN)C3C2O3

Technology Process of 1-(3-Oxatricyclo[3.2.1.0~2,4~]octan-6-yl)methanamine

There total 2 articles about 1-(3-Oxatricyclo[3.2.1.0~2,4~]octan-6-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

exo-3-oxatricyclo<3.2.1.02,4>octane-2-exo-2-carbonitrile → exo-5-aminomethyl-exo-2,3-epoxybicyclo<2.2.1>heptane (220555-34-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

Reference yield:

5-norbornene-2-carbonitrile (2890-96-2) → exo-5-aminomethyl-exo-2,3-epoxybicyclo<2.2.1>heptane (220555-34-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / phthalic anhydride, urea, aq. hydrogen peroxide / ethyl acetate

2: 76 percent / LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; phthalic anhydride; dihydrogen peroxide; urea; In diethyl ether; ethyl acetate;

upstream raw materials:

5-norbornene-2-carbonitrile