N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide
CAS No.:1383452-20-7
Molecular Formula:C₂₅H₂₃FN₄O₅
Molecular Weight:478.48
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide

Suppliers and Price of N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide

There total 8 articles about N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1460-05-5
p-nitrophenylacetaldehyde

: 1383452-12-7
4-amino-N₁-(4-fluorobenzyl)-2-methoxy-N₃-methylisophthalamide

: 1383452-20-7
N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide

Guidance literature:: With magnesium sulfate; toluene-4-sulfonic acid; In ethanol; for 3h; Reflux;
DOI:10.1016/j.ejmech.2012.04.010

Reference yield:

: C₁₇H₂₃NO₆

: 1383452-20-7
N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; water / -15 - 60 °C

2.1: pyridine; potassium permanganate / water / 3 h / 45 - 50 °C

2.2: 0 °C / pH 1 - 2

3.1: triethylamine / tetrahydrofuran / 1 h / -15 °C

4.1: tetrahydrofuran / -15 - 60 °C

5.1: hydrogenchloride / water / 1 h / Reflux

5.2: 0 °C / pH 9 - 10

6.1: magnesium sulfate; toluene-4-sulfonic acid / ethanol / 3 h / Reflux

With pyridine; hydrogenchloride; potassium permanganate; magnesium sulfate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.ejmech.2012.04.010

Reference yield:

: 1383452-11-6
N₁-(4-fluorobenzyl)-2-methoxy-N₃-methyl-4-pivalamidoiso-phthalamide

: 1383452-20-7
N-(4-fluorobenzyl)-5-methoxy-3-methyl-2-(4-nitrobenzyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 1 h / Reflux

1.2: 0 °C / pH 9 - 10

2.1: magnesium sulfate; toluene-4-sulfonic acid / ethanol / 3 h / Reflux

With hydrogenchloride; magnesium sulfate; toluene-4-sulfonic acid; In ethanol; water;
DOI:10.1016/j.ejmech.2012.04.010