(Z)-2-(2-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

Base Information

Chemical Name:(Z)-2-(2-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole
CAS No.:1388841-48-2
Molecular Formula:C₁₃H₇ClF₃N₅O₂
Molecular Weight:357.679
Hs Code.:

Synonyms:(Z)-2-(2-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

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Chemical Property of (Z)-2-(2-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

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Technology Process of (Z)-2-(2-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

There total 4 articles about (Z)-2-(2-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.73%

: 1388842-20-3
(Z)-3-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)acrylohydrazide

: 149-73-5
trimethyl orthoformate

: 1388841-48-2
(Z)-2-(2-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

Guidance literature:: methanesulfonic acid; In tetrahydrofuran; at 70 ℃; for 2h;

Reference yield:

: 1333151-85-1
(Z)-isopropyl 3-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

: 1388841-48-2
(Z)-2-(2-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C

3: hydrazine hydrate / 1 h / 0 °C

4: methanesulfonic acid / tetrahydrofuran / 2 h / 70 °C

With 4-methyl-morpholine; water; hydrazine hydrate; lithium hydroxide; methanesulfonic acid; In tetrahydrofuran;

Reference yield:

: 1388842-19-0
(Z)-3-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

: 1388841-48-2
(Z)-2-(2-(3-(3-chloro-5-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C

2: hydrazine hydrate / 1 h / 0 °C

3: methanesulfonic acid / tetrahydrofuran / 2 h / 70 °C

With 4-methyl-morpholine; hydrazine hydrate; methanesulfonic acid; In tetrahydrofuran;