(2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester
CAS No.:160977-91-3
Molecular Formula:C₃₀H₃₁NO₄
Molecular Weight:469.58
Hs Code.:

Synonyms:(2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of (2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester

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Technology Process of (2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester

There total 2 articles about (2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 160977-89-9
(2S,3S,4S)-4-Isopropenyl-3-methoxycarbonylmethyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester

: 160977-91-3
(2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; methanol; for 8h; Ambient temperature;

Reference yield:

: 487-79-6
(-)-kainic acid

: 160977-91-3
(2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: NaOH

With sodium hydroxide;
DOI:10.1016/0040-4039(95)02000-F

Reference yield:

: 160977-91-3
(2S,3S,4S)-3-Carboxymethyl-4-isopropenyl-1-trityl-pyrrolidine-2-carboxylic acid methyl ester

: Glp-Gln-Phe-Phe-Gly-Leu-Kol(Bzl)-NH₂

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) DCC, HOBt, 2.) NaBH₄

2: NaH

3: TsOH*H₂O / propan-2-ol / Heating

4: DCC, HOBt

5: NH₃

7: BOP

8: TFA / CH₂Cl₂

With sodium tetrahydroborate; ammonia; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;
DOI:10.1016/0040-4039(95)02000-F