Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester

Base Information

• Chemical Name: Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester
• CAS No.: 223791-50-2
• Molecular Formula: C₂₂H₂₆O₃
• Molecular Weight: 338.447
• Mol file: 223791-50-2.mol

Synonyms:Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester

Chemical Property of Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester

There total 4 articles about Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

butyric acid 3-(4-butyryloxy-phenyl)-1,1,3-trimethyl-indan-5-yl ester (223791-49-9) → (R)-(+)-2,3-dihydro-3-(4'-hydroxyphenyl)-1,1,3-trimethyl-1H-inden-5-ol (210295-65-1) + Butyric acid 4-((R)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester + Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester (223791-50-2)

Guidance literature:

butyric acid 3-(4-butyryloxy-phenyl)-1,1,3-trimethyl-indan-5-yl ester; With sodium hydroxide; phosphate buffer; Chromobacterium Viscosum lipase; for 5h; pH=7.2;

With sodium methylate; In methanol; at 20 ℃; for 2h;

DOI:10.1021/jo990795w

Reference yield:

5-hydroxy-3-(4-hydroxyphenyl)-1,1,3-trimethylindane (10527-11-4) → Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester (223791-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 20 °C

2: Chromobacterium viscosum lipase; phosphate buffer; NaOH / 5 h / pH 7.2

With sodium hydroxide; phosphate buffer; Chromobacterium Viscosum lipase; triethylamine; In tetrahydrofuran; 1: Acylation / 2: Hydrolysis;

DOI:10.1021/jo990795w

Reference yield:

butyric acid 3-(4-butyryloxy-phenyl)-1,1,3-trimethyl-indan-5-yl ester (223791-49-9) → Butyric acid 4-((R)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester + Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester (223791-50-2) + Butyric acid (R)-3-(4-butyryloxy-phenyl)-1,1,3-trimethyl-indan-5-yl ester (251450-95-0)

Guidance literature:

With lipase from Chromobacterium viscosum; In phosphate buffer; for 31h; pH=7.2; Title compound not separated from byproducts.;

DOI:10.1021/jo005681v

upstream raw materials:

butyric acid 3-(4-butyryloxy-phenyl)-1,1,3-trimethyl-indan-5-yl ester

5-hydroxy-3-(4-hydroxyphenyl)-1,1,3-trimethylindane