4-[4-(but-2-ynylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Base Information

• Chemical Name: 4-[4-(but-2-ynylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
• CAS No.: 946857-30-3
• Molecular Formula: C₂₄H₃₄N₂O₆S
• Molecular Weight: 478.61
• Mol file: 946857-30-3.mol

Synonyms:4-[4-(but-2-ynylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Chemical Property of 4-[4-(but-2-ynylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-[4-(but-2-ynylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

There total 1 articles about 4-[4-(but-2-ynylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-(4-aminobenzenesulfonylmethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester + 1-Bromo-2-butyne (3355-28-0) → 4-[4-(but-2-ynylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (946857-30-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 100 ℃; for 0.833333h; microwave irradiation;

DOI:10.1016/j.bmc.2007.06.031

Reference yield: 72.0%

4-[4-(but-2-ynylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (946857-30-3) + methyl iodide (74-88-4) → 4-[4-(N-but-2-ynyl-N-methylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:

With silver(l) oxide; at 25 ℃; for 16h;

DOI:10.1016/j.bmc.2007.06.031

Reference yield:

4-[4-(but-2-ynylamino)benzenesulfonylmethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (946857-30-3) → C22H30N2O6S

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 16h;

DOI:10.1016/j.bmc.2007.06.031

upstream raw materials:

1-Bromo-2-butyne