Cyclopropanamine, 2-(4-fluorophenyl)-, (1R,2S)- (9CI)

Base Information

• Chemical Name: Cyclopropanamine, 2-(4-fluorophenyl)-, (1R,2S)- (9CI)
• CAS No.: 220349-80-4
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.184
• Mol file: 220349-80-4.mol

Synonyms:Cyclopropanamine, 2-(4-fluorophenyl)-, (1R,2S)- (9CI)

Chemical Property of Cyclopropanamine, 2-(4-fluorophenyl)-, (1R,2S)- (9CI)

Chemical Property:

• PSA: 26.02000
• LogP: 2.34060

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

(1R,2S)-2-(4-Fluorophenyl)cyclopropanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (1R,2S)-2-(4-Fluorophenyl)cyclopropanamine is an impurity of Ticagrelor (T437700), [274693-27-5].

Technology Process of Cyclopropanamine, 2-(4-fluorophenyl)-, (1R,2S)- (9CI)

There total 14 articles about Cyclopropanamine, 2-(4-fluorophenyl)-, (1R,2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1R,2S)-tert-butyl 2-(4-fluorophenyl)cyclopropylcarbamate (1314323-96-0) → (1R,2S)-2-(4-fluorophenyl)cyclopropan-1-amine (113516-71-5,220349-80-4)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1h;

Reference yield:

cis-2-[2-(4-fluoro-phenyl)-cyclopropyl]-1,3-isoindoledione → 2-cis-(4-fluoro-phenyl)-cyclopropylamine (113516-71-5,220349-80-4)

Guidance literature:

With hydrazine hydrate; In ethanol; dichloromethane; at 20 ℃; for 3h;

Reference yield:

2-((1R,2S)-2-(4-fluorophenyl)cyclopropyl)isoindoline-1,3-dione → (1R,2S)-2-(4-fluorophenyl)cyclopropan-1-amine (113516-71-5,220349-80-4)

Guidance literature:

With hydrazine; In ethanol; dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid

methyl (2E)-3-(4-fluorophenyl)-2-propenoate

(E)-4-fluorocinnamic acid

methyl 2-(4-fluorophenyl)cyclopropane-1-carboxylate

Refernces

• 1、 -. "CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS". Page/Page column 143. . Retrieved 2017/12/01.
• 2、 -. "KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE". . . Retrieved 2014/10/18.