METHYL 4-FLUOROCINNAMATE 97% PREDOMIN&

Base Information

• Chemical Name: METHYL 4-FLUOROCINNAMATE 97% PREDOMIN&
• CAS No.: 96426-60-7
• Molecular Formula: C₁₀H₉FO₂
• Molecular Weight: 180.179
• Mol file: 96426-60-7.mol

Synonyms:METHYL 4-FLUOROCINNAMATE,, PREDOMIN;2-PROPENOIC ACID, 3-(4-FLUOROPHENYL)-, METHYL ESTER;methyl p-Fluorobenzoylacetate;METHYL 4-FLUOROCINNAMATE PREDOMIN;(E)-methyl 3-(4-fluorophenyl)acrylate;Methyl 3-(4-fluorophenyl)-3-oxopropionate;Methyl 4-fluorocinnamate, predominantly trans;METHYL 4-FLUOROCINNAMATE;methyl trans-4-fluorocinnamate;methyl (E)-3-(4-fluorophenyl)-2-propenoate;3-(4-fluorophenyl)-3-oxopropionic acid methyl ester;METHYL4-FLUOROCINNAMATE;(E)-methyl-3-(p-fluorophenyl)acrylate;4-fluorocinnamic acid methyl ester;Methyl 4-fluorobenzoylacetate;methyl p-fluorocinnamate;methyl 3-(4-fluorophenyl)-2-propenoate;

Chemical Property of METHYL 4-FLUOROCINNAMATE 97% PREDOMIN&

Chemical Property:

• Vapor Pressure: 0.0201mmHg at 25°C
• Melting Point: 45-49oC(lit.)
• Boiling Point: 251.7oC at 760 mmHg
• Flash Point: >230 °F
• PSA: 26.30000
• Density: 1.165g/cm3
• LogP: 2.01190
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(E)-Methyl3-(4-Fluorophenyl)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-FLUOROCINNAMATE 97% PREDOMIN&

There total 51 articles about METHYL 4-FLUOROCINNAMATE 97% PREDOMIN& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 4-fluorocinnamic acid (459-32-5,14290-66-5,14290-86-9) → methyl p-fluorocinnamate (100891-10-9,96426-60-7)

Guidance literature:

With thionyl chloride; at 20 ℃; for 18h;

DOI:10.1016/S0957-4166(01)00069-6

Reference yield: 95.0%

methanol (67-56-1) + (E)-4-fluorocinnamic acid (459-32-5) → methyl (2E)-3-(4-fluorophenyl)-2-propenoate (96426-60-7,100891-10-9)

Guidance literature:

With sulfuric acid; for 2h; Heating;

DOI:10.1016/S0968-0896(97)10017-7

Reference yield: 95.0%

4-fluoro-1-iodobenzene (352-34-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl (2E)-3-(4-fluorophenyl)-2-propenoate (96426-60-7,100891-10-9)

Guidance literature:

With {1-[3-(MeO)3Si(CH₂)3]-3-Me-4-imidazolin-2-yl}2PdCl₂; sodium acetate; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 4h;

DOI:10.1021/ol060129z

upstream raw materials:

4-fluorobenzaldehyde

bromoacetic acid methyl ester

methanol

4-fluorocinnamic acid

Downstream raw materials:

trans-methyl 2-(4-fluorophenyl)cyclopropanecarboxylate

3-(4-Fluorophenyl)propionic acid,methyl ester

dimethyl 2-cyano-3-(4-fluorophenyl)glutarate

3-(4-fluorophenyl)prop-2-en-1-ol

Refernces

• 1、 Cao, Jiafu,Li, Qiji,Liao, Xiu,Wang, Enhua,Wang, Li,Yang, Juan,Yang, Lishou,Yang, Qian,Yang, Xiaosheng,Yang, Yan. "Synthesis of novel 1-phenyl-benzopyrrolizidin-3-one derivatives and evaluation of their cytoneuroprotective effects against NMDA-induced injury in PC12 cells". . . Retrieved 2022/02/23.
• 2、 -. "TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS AND COMPOUNDS FOR SAME". Page/Page column 49; 52; 54. . Retrieved 2021/09/17.