3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(trifluoromethyl)benzamide
CAS No.:1403590-64-6
Molecular Formula:C₂₃H₂₈F₃N₃O₂
Molecular Weight:435.489
Hs Code.:

Synonyms:3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(trifluoromethyl)benzamide

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Chemical Property of 3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(trifluoromethyl)benzamide

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Technology Process of 3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(trifluoromethyl)benzamide

There total 3 articles about 3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403595-59-4
C₁₅H₁₈F₃NO₂

: 1403590-64-6
3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(trifluoromethyl)benzamide

Guidance literature:: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C₁₅H₁₈F₃NO₂; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide;

Reference yield:

: 13055-63-5
2-methyl-5-(trifluoromethyl)benzoic acid

: 1403590-64-6
3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2.1: hydrogen / palladium(II) hydroxide / methanol / 3 h

3.1: acetic acid / methanol / 3 h

4.1: caesium carbonate / acetonitrile / 8 h / 80 °C

5.1: sodium hydroxide; water / methanol / 1 h / 60 °C

5.2: pH 4 - 6

6.1: dimethyl sulfoxide / 0.25 h / 20 °C

With water; hydrogen; sodium carbonate; caesium carbonate; acetic acid; sodium hydroxide; palladium(II) hydroxide; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1396780-64-5
methyl 2-methyl-3-nitro-5-(trifluoromethyl)benzoate

: 1403590-64-6
3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium(II) hydroxide / methanol / 3 h

2.1: acetic acid / methanol / 3 h

3.1: caesium carbonate / acetonitrile / 8 h / 80 °C

4.1: sodium hydroxide; water / methanol / 1 h / 60 °C

4.2: pH 4 - 6

5.1: dimethyl sulfoxide / 0.25 h / 20 °C

With water; hydrogen; caesium carbonate; acetic acid; sodium hydroxide; palladium(II) hydroxide; In methanol; dimethyl sulfoxide; acetonitrile;