(E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Base Information

Chemical Name:(E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole
CAS No.:1350920-04-5
Molecular Formula:C₁₉H₁₅F₃N₂O₃
Molecular Weight:376.335
Hs Code.:

Synonyms:(E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Suppliers and Price of (E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

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Technology Process of (E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

There total 3 articles about (E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 477886-85-4
5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

: 1059544-14-7
trans-4-(2-iodovinyl)-1,2-dimethoxybenzene

: 1350920-04-5
(E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Guidance literature:: With copper(l) iodide; lithium tert-butoxide; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 70 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2011.10.049

Reference yield:

: 14737-89-4
3,4-dimethoxy-trans-cinnamic acid

: 1350920-04-5
(E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.08 h / 20 °C

1.2: 0.17 h / 20 °C

2.1: copper(l) iodide; lithium tert-butoxide; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 3 h / 70 °C / Inert atmosphere

With copper(l) iodide; triethylamine; lithium tert-butoxide; N,N`-dimethylethylenediamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2011.10.049

Reference yield:

: 339-59-3
4-(trifluoromethyl)benzoic acid hydrazide

: 1350920-04-5
(E)-2-(3,4-dimethoxystyryl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 120 °C

2: copper(l) iodide; lithium tert-butoxide; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 3 h / 70 °C / Inert atmosphere

With copper(l) iodide; lithium tert-butoxide; N,N`-dimethylethylenediamine; In dimethyl sulfoxide;
DOI:10.1016/j.tet.2011.10.049