2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-5-thiazoleacetamide

Base Information

Chemical Name:2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-5-thiazoleacetamide
CAS No.:929561-53-5
Molecular Formula:C₂₂H₂₂ClN₃O₅S
Molecular Weight:475.953
Hs Code.:

Synonyms:2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-5-thiazoleacetamide

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Chemical Property of 2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-5-thiazoleacetamide

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Technology Process of 2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-5-thiazoleacetamide

There total 6 articles about 2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-5-thiazoleacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929562-65-2
C₂₁H₁₉ClN₂O₆S

: 593-51-1
methylamine hydrochloride

: 929561-53-5
2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-5-thiazoleacetamide

Guidance literature:: With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; for 2h; Reflux;

Reference yield:

: 929562-37-8
C₁₉H₁₇ClN₂O₄S

: 929561-53-5
2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-5-thiazoleacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0.05 h / 120 °C / Microwave irradiation

2: boron trifluoride diethyl etherate / dichloromethane / 2.75 h / 20 °C / Cooling with acetone-dry ice

3: hydrogenchloride; water; acetic acid / 1 h / Reflux

4: potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / Reflux

With hydrogenchloride; boron trifluoride diethyl etherate; water; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 4629-54-3
2-bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone

: 929561-53-5
2-[(5-chloro-2,4-dimethoxyphenyl)amino]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-5-thiazoleacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 4 h / Reflux

1.2: 0.5 h

2.1: triethylamine / tetrahydrofuran / 0.05 h / 120 °C / Microwave irradiation

3.1: boron trifluoride diethyl etherate / dichloromethane / 2.75 h / 20 °C / Cooling with acetone-dry ice

4.1: hydrogenchloride; water; acetic acid / 1 h / Reflux

5.1: potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / Reflux

With hydrogenchloride; boron trifluoride diethyl etherate; water; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;