1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N³-benzoylthymine

Base Information

• Chemical Name: 1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N³-benzoylthymine
• CAS No.: 241817-12-9
• Molecular Formula: C₃₈H₄₂N₂O₉Si
• Molecular Weight: 698.845

Synonyms:1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N³-benzoylthymine

Chemical Property of 1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N³-benzoylthymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N³-benzoylthymine

There total 6 articles about 1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N³-benzoylthymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzoyl chloride (98-88-4) + 1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>thymine (241817-10-7) → 1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N3-benzoylthymine (241817-12-9)

Guidance literature:

With pyridine; at 80 ℃;

DOI:10.1016/S0968-0896(99)00061-9

Reference yield:

thymin (65-71-4,28806-14-6,691841-57-3) → 1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N3-benzoylthymine (241817-12-9)

Guidance literature:

Multi-step reaction with 3 steps

1: (NH₄)2SO₄ / Heating

2: 62 percent / TMSOTf / CH₂Cl₂ / 1.) room temperature, overnight, 2.) 50 deg C, 24 h

3: 70 percent / pyridine / 80 °C

With pyridine; ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; In dichloromethane;

DOI:10.1016/S0968-0896(99)00061-9

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N3-benzoylthymine (241817-12-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

2: 62 percent / TMSOTf / CH₂Cl₂ / 1.) room temperature, overnight, 2.) 50 deg C, 24 h

3: 70 percent / pyridine / 80 °C

With pyridine; 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(99)00061-9

upstream raw materials:

benzoyl chloride

1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>thymine

thymin

tert-butylchlorodiphenylsilane

Downstream raw materials:

1-<3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-2-O-(2-methoxyethoxymethyl)-β-D-erythro-pentofuranosyl>thymine

1-<3-deoxy-3-C-hydroxymethyl-2-O-(2-methoxyethoxymethyl)-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>thymine

1-<5-O-benzoyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N³-benzoylthymine

1-<5-O-benzoyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-2-O-(2-methoxyethoxymethyl)-β-D-erythro-pentofuranosyl>-N³-benzoylthymine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 241817-12-9 1-<2,5-di-O-acetyl-3-C-(tert-butyldiphenyl)siloxymethyl-3-deoxy-β-D-erythro-pentofuranosyl>-N³-benzoylthymine

Send

Send

Metric Ton KG G Pound L ML

Send

Send