Cbz-L-(αMe)Val-L-Phe-OMe

Base Information

• Chemical Name: Cbz-L-(αMe)Val-L-Phe-OMe
• CAS No.: 711015-19-9
• Molecular Formula: C₂₄H₃₀N₂O₅
• Molecular Weight: 426.513
• Mol file: 711015-19-9.mol

Synonyms:Cbz-L-(αMe)Val-L-Phe-OMe

Chemical Property of Cbz-L-(αMe)Val-L-Phe-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-L-(αMe)Val-L-Phe-OMe

There total 3 articles about Cbz-L-(αMe)Val-L-Phe-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

D-phenylalanine methyl ester hydrochloride (13033-84-6) + (S)-(+)-2-benzyloxycarbonylamino-2,3-dimethylbutanoic acid (137584-40-8) → Cbz-L-(αMe)Val-L-Phe-OMe (711015-19-9)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1021/jo040107v

Reference yield:

(S)-α-Methylvaline (4378-19-2,26287-62-7,53940-82-2,53940-83-3) → Cbz-L-(αMe)Val-L-Phe-OMe (711015-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / acetonitrile; H₂O

2: 88 percent / HOAt; EDC*HCl; NMM / CH₂Cl₂ / 72 h / 20 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; TEA; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; acetonitrile;

DOI:10.1021/jo040107v

Reference yield:

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) → Cbz-L-(αMe)Val-L-Phe-OMe (711015-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / acetonitrile; H₂O

2: 88 percent / HOAt; EDC*HCl; NMM / CH₂Cl₂ / 72 h / 20 °C

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; TEA; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; acetonitrile;

DOI:10.1021/jo040107v

upstream raw materials:

D-phenylalanine methyl ester hydrochloride

(S)-(+)-2-benzyloxycarbonylamino-2,3-dimethylbutanoic acid

N-(Benzyloxycarbonyloxy)succinimide

(S)-α-Methylvaline

Downstream raw materials:

Cbz-D-Pro-L-(αMe)Val-L-Phe-OMe

Refernces