1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one

Base Information

Chemical Name:1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one
CAS No.:1404285-89-7
Molecular Formula:C₂₃H₂₁NO₂S
Molecular Weight:375.491
Hs Code.:

Synonyms:1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one

Suppliers and Price of 1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one

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Technology Process of 1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one

There total 4 articles about 1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1-benzyl-4-ethynylpiperidin-4-yl 5-phenyl-1,2,3-thiadiazole-4-carboxylate

: 1404285-89-7
1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In chlorobenzene; at 130 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.joc.6b02614

Reference yield: 25.0%

: 591-50-4
iodobenzene

: 1404285-88-6
1-benzylspiro(piperidine-4,1'-thieno[3,4-c]furan)-3'-one

: 1404285-89-7
1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one

: 1404285-90-0
1-benzyl-6'-phenylspiro(piperidine-4,1'-thieno[3,4-c]furan)-3'-one?

: 1404285-91-1
1-benzyl-4',6'-diphenylspiro(piperidine-4,1'-thieno[3,4-c]furan)-3'-one

Guidance literature:: With [2,2]bipyridinyl; silver (II) carbonate; palladium dichloride; In m-xylene; at 150 ℃; for 12h; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201200837

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1404285-89-7
1-benzyl-4′-phenyl-3′H-spiro[piperidine-4,1′-thieno[3,4-c]furan]-3′-one

: 1404285-90-0
1-benzyl-6'-phenylspiro(piperidine-4,1'-thieno[3,4-c]furan)-3'-one?

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.42 h / -78 °C / Inert atmosphere

1.2: 0.67 h / -78 °C / Inert atmosphere

2.1: acetic anhydride; sodium acetate / toluene / 125 °C

3.1: palladium dichloride; silver (II) carbonate; [2,2]bipyridinyl / m-xylene / 12 h / 150 °C / Inert atmosphere

With [2,2]bipyridinyl; silver (II) carbonate; n-butyllithium; sodium acetate; acetic anhydride; palladium dichloride; In diethyl ether; hexane; m-xylene; toluene;
DOI:10.1002/ejoc.201200837