8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate

Base Information

Chemical Name:8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate
CAS No.:177556-96-6
Molecular Formula:C₃₂H₂₈N₂O₃
Molecular Weight:488.586
Hs Code.:

Synonyms:8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate

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Technology Process of 8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate

There total 11 articles about 8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 177556-96-6
8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate

Guidance literature:

Reference yield:

: 1026295-45-3
(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-ethyl-indolizin-1-yl)-oxo-acetyl chloride

: 177556-96-6
8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; Yield given; Ambient temperature;
DOI:10.1021/jm960395q

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 177556-96-6
8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 46 percent / Et₃N / 90 °C

2: 50percent aq. KOH / dimethylsulfoxide / 140 °C

3: toluene / 1 h / Heating

4: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

5: tetrahydrofuran / 0 °C

6: aq. NH₄OH / tetrahydrofuran / Ambient temperature

With potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; aluminium trichloride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/jm960395q