8-hydroxy-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetatate

Base Information

Chemical Name:8-hydroxy-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetatate
CAS No.:177558-91-7
Molecular Formula:C₂₅H₂₂N₂O₃
Molecular Weight:398.461
Hs Code.:

Synonyms:8-hydroxy-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetatate

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Chemical Property of 8-hydroxy-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetatate

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Technology Process of 8-hydroxy-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetatate

There total 11 articles about 8-hydroxy-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetatate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 177556-96-6
8-benzyl-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetate

: 177558-91-7
8-hydroxy-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetatate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm960395q

Reference yield: 95.0%

: 177558-91-7
8-hydroxy-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetatate

Guidance literature:

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 177558-91-7
8-hydroxy-2-(1-(2-amino-2-oxoacetyl)-2-(ethyl-3-(o-phenylbenzyl))indolizin-8-yloxy)acetatate

Guidance literature:: Multi-step reaction with 7 steps

1: 46 percent / Et₃N / 90 °C

2: 50percent aq. KOH / dimethylsulfoxide / 140 °C

3: toluene / 1 h / Heating

4: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

5: tetrahydrofuran / 0 °C

6: aq. NH₄OH / tetrahydrofuran / Ambient temperature

7: 95 percent / H₂ / 10percent Pd/C / ethyl acetate

With potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; aluminium trichloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1021/jm960395q