2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid

Base Information

Chemical Name:2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid
CAS No.:1262007-78-2
Molecular Formula:C₂₇H₂₈ClF₃N₂O₃
Molecular Weight:520.979
Hs Code.:

Synonyms:2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid

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Chemical Property of 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid

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Technology Process of 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid

There total 10 articles about 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262008-92-3
tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

: 1262007-78-2
2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid

Guidance literature:: With rac-cysteine; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1262008-98-9
tert-butyl 3-(5-(benzyloxy)-1-(2-hydroxyethyl)-1H-indol-2-yl)acrylate

: 1262007-78-2
2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: dmap / dichloromethane / 0.5 h / 0 °C

2: tetrahydrofuran / 2.5 h / 120 °C / microwave irradiation

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 8 h / 65 °C

5: N-chloro-succinimide / dichloromethane / 1 h / 0 °C

6: trifluoroacetic acid; rac-cysteine / dichloromethane / 0 - 20 °C

With dmap; N-chloro-succinimide; rac-cysteine; hydrogen; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: tert-butyl 3-(5-(benzyloxy)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-indol-2-yl)acrylate

: 1262007-78-2
2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

2: dmap / dichloromethane / 0.5 h / 0 °C

3: tetrahydrofuran / 2.5 h / 120 °C / microwave irradiation

4: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 8 h / 65 °C

6: N-chloro-succinimide / dichloromethane / 1 h / 0 °C

7: trifluoroacetic acid; rac-cysteine / dichloromethane / 0 - 20 °C

With dmap; N-chloro-succinimide; rac-cysteine; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;