tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

Base Information

Chemical Name:tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate
CAS No.:1262008-92-3
Molecular Formula:C₃₁H₃₆ClF₃N₂O₃
Molecular Weight:577.087
Hs Code.:

Synonyms:tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

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Chemical Property of tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

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Technology Process of tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

There total 7 articles about tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262008-91-2
tert-butyl 2-(8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

: 1262008-92-3
tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

Guidance literature:: With N-chloro-succinimide; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: tert-butyl 3-(5-(benzyloxy)-1H-indol-2-yl)acrylate

: 1262008-92-3
tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 80 °C / sealed tube

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

3: dmap / dichloromethane / 0.5 h / 0 °C

4: tetrahydrofuran / 2.5 h / 120 °C / microwave irradiation

5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 8 h / 65 °C

7: N-chloro-succinimide / dichloromethane / 1 h / 0 °C

With dmap; N-chloro-succinimide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1262008-98-9
tert-butyl 3-(5-(benzyloxy)-1-(2-hydroxyethyl)-1H-indol-2-yl)acrylate

: 1262008-92-3
tert-butyl 2-(10-chloro-8-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / dichloromethane / 0.5 h / 0 °C

2: tetrahydrofuran / 2.5 h / 120 °C / microwave irradiation

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 8 h / 65 °C

5: N-chloro-succinimide / dichloromethane / 1 h / 0 °C

With dmap; N-chloro-succinimide; hydrogen; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;