2'-O-acetyl-3'-chloro-3'-deoxy-5'-S-(4-methoxyphenyl)-5'-thioadenosine

Base Information

Chemical Name:2'-O-acetyl-3'-chloro-3'-deoxy-5'-S-(4-methoxyphenyl)-5'-thioadenosine
CAS No.:203584-09-2
Molecular Formula:C₁₉H₂₀ClN₅O₄S
Molecular Weight:449.918
Hs Code.:

Synonyms:2'-O-acetyl-3'-chloro-3'-deoxy-5'-S-(4-methoxyphenyl)-5'-thioadenosine

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Chemical Property of 2'-O-acetyl-3'-chloro-3'-deoxy-5'-S-(4-methoxyphenyl)-5'-thioadenosine

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Technology Process of 2'-O-acetyl-3'-chloro-3'-deoxy-5'-S-(4-methoxyphenyl)-5'-thioadenosine

There total 7 articles about 2'-O-acetyl-3'-chloro-3'-deoxy-5'-S-(4-methoxyphenyl)-5'-thioadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 108-24-7
acetic anhydride

: 203584-06-9
(2R,3S,4S,5R)-2-(6-Amino-purin-9-yl)-4-chloro-5-(4-methoxy-phenylsulfanylmethyl)-tetrahydro-furan-3-ol

: 203584-09-2
2'-O-acetyl-3'-chloro-3'-deoxy-5'-S-(4-methoxyphenyl)-5'-thioadenosine

Guidance literature:: In pyridine; at 0 ℃; for 7.5h;
DOI:10.1021/jo971741u

Reference yield:

: 70147-60-3
3',5'-dichloro-3',5'-dideoxy-adenosine

: 203584-09-2
2'-O-acetyl-3'-chloro-3'-deoxy-5'-S-(4-methoxyphenyl)-5'-thioadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaH / dimethylformamide / -20 - 20 °C

2: 99 percent / pyridine / 7.5 h / 0 °C

With sodium hydride; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jo971741u

Reference yield:

: 696-63-9
4-Methoxybenzenethiol

: 203584-09-2
2'-O-acetyl-3'-chloro-3'-deoxy-5'-S-(4-methoxyphenyl)-5'-thioadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaH / dimethylformamide / -20 - 20 °C

2: 99 percent / pyridine / 7.5 h / 0 °C

With sodium hydride; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jo971741u