(S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester

Base Information

• Chemical Name: (S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester
• CAS No.: 1185234-46-1
• Molecular Formula: C₁₁H₁₂F₂O₃
• Molecular Weight: 230.211
• Mol file: 1185234-46-1.mol

Synonyms:(S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester

Chemical Property of (S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester

There total 2 articles about (S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

ethyl 2-(3,5-difluorophenyl)-2-oxoacetate (208259-57-8) → (S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester (1185234-46-1)

Guidance literature:

ethyl 2-(3,5-difluorophenyl)-2-oxoacetate; With dimethyl zinc(II); (S)-N-benzylmandelamide; In toluene; at 0 ℃; for 4h;

With hydrogenchloride; In water; toluene;

Reference yield: 58.0%

ethyl 2-(3,5-difluorophenyl)-2-oxoacetate (208259-57-8) + dimethyl zinc(II) (544-97-8) → (S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester (1185234-46-1)

Guidance literature:

ethyl 2-(3,5-difluorophenyl)-2-oxoacetate; dimethyl zinc(II); With (S)-N-benzylmandelamide; In toluene; at 0 ℃; for 4h;

With hydrogenchloride; In water; toluene;

Reference yield: 80.0%

(S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester (1185234-46-1) + 4-Bromo-1-fluoro-2-nitrobenzene (364-73-8) → (S)-7-bromo-3-(3,5-difluorophenyl)-3-methyl-benzo[2,3-b][1,4]oxazin-2(3H)-one

Guidance literature:

(S)-2-(3,5-difluorophenyl)-2-hydroxy-propionic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

4-Bromo-1-fluoro-2-nitrobenzene; 15-crown-5; In tetrahydrofuran; mineral oil; at 20 ℃; for 17h;

With iron; acetic acid; at 60 ℃; for 4h;

upstream raw materials:

ethyl 2-(3,5-difluorophenyl)-2-oxoacetate

dimethyl zinc(II)