3-Pyridinepropanoicacid,-alpha--amino-6-bromo-(9CI)

Base Information

• Chemical Name: 3-Pyridinepropanoicacid,-alpha--amino-6-bromo-(9CI)
• CAS No.: 32938-58-2
• Molecular Formula: C₈H₉BrN₂O₂
• Molecular Weight: 245.076
• Mol file: 32938-58-2.mol

Synonyms:3-Pyridinepropanoicacid, a-amino-6-bromo-, (?à)-; 3-Pyridinepropionic acid, a-amino-6-bromo-, DL- (8CI)

Chemical Property of 3-Pyridinepropanoicacid,-alpha--amino-6-bromo-(9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Pyridinepropanoicacid,-alpha--amino-6-bromo-(9CI)

There total 3 articles about 3-Pyridinepropanoicacid,-alpha--amino-6-bromo-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (S)-2-amino-3-(6-bromopyridin-3-yl)propanoate (462123-61-1) → (S)-2-amino-3-(6-bromopyridin-3-yl)propanoic acid (1161498-20-9,32938-58-2)

Guidance literature:

tert-butyl (S)-2-amino-3-(6-bromopyridin-3-yl)propanoate; With trifluoroacetic acid; In dichloromethane; for 0.5h;

With acetic acid; In acetonitrile;

Reference yield:

(E)-3-(6-bromopyridin-3-yl)acrylic acid (924628-44-4) → (S)-2-amino-3-(6-bromopyridin-3-yl)propanoic acid (1161498-20-9,32938-58-2)

Guidance literature:

With phenylalanine ammonia lyase from Anabaena variabilis; ammonium carbamate; In water; at 37 ℃; for 22h; pH=9; enantioselective reaction; Enzymatic reaction;

DOI:10.1021/acs.orglett.6b02559

Reference yield:

6-bromonicotinaldehyde (149806-06-4) → (S)-2-amino-3-(6-bromopyridin-3-yl)propanoic acid (1161498-20-9,32938-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dimethyl sulfoxide / 16 h / 100 °C

2: ammonium carbamate; phenylalanine ammonia lyase from Anabaena variabilis / water / 22 h / 37 °C / pH 9 / Enzymatic reaction

With piperidine; phenylalanine ammonia lyase from Anabaena variabilis; ammonium carbamate; In water; dimethyl sulfoxide;

DOI:10.1021/acs.orglett.6b02559

upstream raw materials:

tert-butyl (S)-2-amino-3-(6-bromopyridin-3-yl)propanoate

(E)-3-(6-bromopyridin-3-yl)acrylic acid

6-bromonicotinaldehyde