(1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene

Base Information

• Chemical Name: (1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene
• CAS No.: 339058-27-4
• Molecular Formula: C₂₉H₃₃NO
• Molecular Weight: 411.587
• Mol file: 339058-27-4.mol

Synonyms:(1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene

Chemical Property of (1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene

There total 5 articles about (1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pyrrolidine (123-75-1) + (1Z)-2-benzyl-1-[4-(2-chloroethoxy)phenyl]-1-phenylbutene → (1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene (339058-27-4)

Guidance literature:

In N,N-dimethyl-formamide; at 65 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ejoc.201600959

Reference yield: 60.0%

(Z)-1-iodo-1-phenyl-2-phenylmethyl-1-butene (1243000-91-0) + C12H16BrNOZn (1243000-95-4) → (1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene (339058-27-4)

Guidance literature:

(Z)-1-iodo-1-phenyl-2-phenylmethyl-1-butene; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; Inert atmosphere;

C₁₂H₁₆BrNOZn; In tetrahydrofuran; at 60 ℃; for 14h; Inert atmosphere;

DOI:10.1002/chem.201001061

Reference yield:

phenylboronic acid (98-80-6) → (1Z)-2-benzyl-1-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}butene (339058-27-4)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium phosphate; triphenylphosphine; palladium diacetate / toluene; water / 16 h / 45 °C / Inert atmosphere

2: potassium phosphate; palladium diacetate; ruphos / toluene; water / 24 h / 50 °C / Inert atmosphere

3: PdCl₂(SPhos)2 / tetrahydrofuran / 24 h / 45 °C / Inert atmosphere

4: N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

With potassium phosphate; PdCl₂(SPhos)2; palladium diacetate; triphenylphosphine; ruphos; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 1: |Suzuki Coupling / 2: |Suzuki Coupling / 3: |Negishi Coupling;

DOI:10.1002/ejoc.201600959

upstream raw materials:

(Z)-1-iodo-1-phenyl-2-phenylmethyl-1-butene

C₁₂H₁₆BrNOZn

phenylboronic acid

tris(benzyl)aluminum