(R,R)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(3,5-DIMETHYLPHENYL)PHOSPHINO]BUTANE

Base Information

• Chemical Name: (R,R)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(3,5-DIMETHYLPHENYL)PHOSPHINO]BUTANE
• CAS No.: 220196-29-2
• Molecular Formula: C₃₉H₄₈O₂P₂
• Molecular Weight: 610.756
• Mol file: 220196-29-2.mol

Synonyms:(R,R)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(3,5-DIMETHYLPHENYL)PHOSPHINO]BUTANE;(S,S)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(3,5-DIMETHYLPHENYL)PHOSPHINO]BUTANE

Chemical Property of (R,R)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(3,5-DIMETHYLPHENYL)PHOSPHINO]BUTANE

Chemical Property:

• PSA: 45.64000
• LogP: 8.23950

Purity/Quality:

97% ^*data from raw suppliers

(R,R)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(3,5-DIMETHYLPHENYL)PHOSPHINO]BUTANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R,R)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(3,5-DIMETHYLPHENYL)PHOSPHINO]BUTANE

There total 11 articles about (R,R)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(3,5-DIMETHYLPHENYL)PHOSPHINO]BUTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C39H48O4P2 (1380504-57-3) → (2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-dimethylphenyl)phosphino]butane (71359-96-1,220196-29-2)

Guidance literature:

With diethoxymethylane; Bis(p-nitrophenyl) phosphate; In toluene; at 110 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jacs.1c06697

Reference yield:

sodium bis(3,5-dimethylphenyl)phosphanide + (+)-(2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-dibromobutane (73744-64-6) → (2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-dimethylphenyl)phosphino]butane (71359-96-1,220196-29-2)

Guidance literature:

In tetrahydrofuran; at 40 ℃; Inert atmosphere;

Reference yield:

P(3,5-xylyl)2Li → trans-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-dimethylphenyl)phosphino]butane (220196-29-2)

Guidance literature:

In tetrahydrofuran; for 2h; Heating / reflux;

upstream raw materials:

(+)-(2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-dichlorobutane

diethyl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate

2,3-O-isopropylidene-L-threitol

(4S,5S)-2,2-dimethyl-4,5-bis(p-toluenesulfonyloxymethyl)-1,3-dioxolan