5-[(S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Base Information

Chemical Name:5-[(S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine
CAS No.:1427311-67-8
Molecular Formula:C₂₂H₂₉IN₄O₈
Molecular Weight:604.399
Hs Code.:

Synonyms:5-[(S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[(S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Chemical Property:

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Technology Process of 5-[(S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

There total 12 articles about 5-[(S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₅₇IN₄O₈Si₂

: 1427311-67-8
5-[(S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 1028383-90-5
N³-tert-butyloxycarbonyl-5-bromomethyl-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyuridine

: 1427311-67-8
5-[(S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Guidance literature:: Multi-step reaction with 6 steps

1: 0.75 h / 110 °C / Inert atmosphere

2: ammonium fluoride / methanol / 12 h / 50 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C

4: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

5: ammonia / 1,4-dioxane / 90 °C / Sealed tube

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; dmap; ammonium fluoride; tetrabutyl ammonium fluoride; ammonia; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 766-85-8
3-methoxy-1-iodobenzene

: 1427311-67-8
5-[(S)-1-(4-iodo-5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium nitrite; acetic acid; nitric acid / 24 h / 20 °C

1.2: 60 °C

2.1: phenylmagnesium chloride / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

2.2: 3 h / -30 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: dmap / dichloromethane / 20 °C / Inert atmosphere

4.1: ethanol / Reflux

5.1: potassium carbonate; methanol / 1 h / Reflux

6.1: 0.75 h / 110 °C / Inert atmosphere

7.1: ammonium fluoride / methanol / 12 h / 50 °C

8.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C

9.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

10.1: ammonia / 1,4-dioxane / 90 °C / Sealed tube

11.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; methanol; dmap; ammonium fluoride; phenylmagnesium chloride; tetrabutyl ammonium fluoride; ammonia; nitric acid; potassium carbonate; acetic acid; triethylamine; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;