5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)-N⁴-benzoylcytidine

Base Information

• Chemical Name: 5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)-N⁴-benzoylcytidine
• CAS No.: 81246-77-7
• Molecular Formula: C₄₉H₆₃N₃O₈Si₂
• Molecular Weight: 878.226

Synonyms:5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)-N⁴-benzoylcytidine

Chemical Property of 5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)-N⁴-benzoylcytidine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)-N⁴-benzoylcytidine

There total 1 articles about 5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)-N⁴-benzoylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 4-N-benzoyl-1-(5-O-dimethoxytrityl-β-D-ribofuranosyl)cytosine (81246-76-6,87418-76-6,129666-73-5) → 5'-dimethoxytrityl 3'-tert-butyldimethyl silyl N-benzoylcytidine (81246-78-8) + 5’-O-(1,1-bis(4-methoxyphenyl)-1-phenylmethyl)-2’-O-tert-butyldimethylsilylcytidine (129666-74-6,81256-87-3) + 5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)-N4-benzoylcytidine (81246-77-7)

Guidance literature:

With 1H-imidazole; In pyridine; for 4h; Ambient temperature;

DOI:10.1139/v82-021

Reference yield: 86.0%

5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)-N4-benzoylcytidine (81246-77-7) → 5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)cytidine (82444-77-7)

Guidance literature:

With pyridine; ammonium hydroxide; at 37 ℃; for 72h;

DOI:10.1021/jo00140a005

Reference yield:

5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)-N4-benzoylcytidine (81246-77-7) → N4-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)cytidine (72409-40-6)

Guidance literature:

With benzenesulfonic acid; In methanol; dichloromethane; for 0.0333333h; Ambient temperature;

DOI:10.1021/jo00140a005

upstream raw materials:

tert-butyldimethylsilyl chloride

4-N-benzoyl-1-(5-O-dimethoxytrityl-β-D-ribofuranosyl)cytosine

Downstream raw materials:

5'-O-(dimethoxytrityl)-2',3'-O-bis(tert-butyldimetylsilyl)cytidine

N⁴-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)cytidine

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