N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester

Base Information

Chemical Name:N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester
CAS No.:1384457-99-1
Molecular Formula:C₂₁H₃₃N₂O₈P
Molecular Weight:472.475
Hs Code.:

Synonyms:N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester

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Chemical Property of N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester

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Technology Process of N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester

There total 4 articles about N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1384457-98-0
N-(N-benzyloxycarbonyl-L-leucyl)-2-(methoxy)glycine methyl ester

: 122-52-1
triethyl phosphite

: 1384457-99-1
N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol301676z

Reference yield: 71.0%

: 40290-56-0
Cbz-Leu-Ser-OMe

: 122-52-1
triethyl phosphite

: 1384457-99-1
N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester

Guidance literature:: Cbz-Leu-Ser-OMe; With iodine; lead(IV) tetraacetate; In dichloromethane; at 26 ℃; for 1h; Inert atmosphere; Irradiation;

triethyl phosphite; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol301676z

Reference yield:

: 40290-56-0
Cbz-Leu-Ser-OMe

: 1384457-99-1
N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: iodine; lead(IV) tetraacetate / dichloromethane / 1 h / 26 °C / Inert atmosphere; Irradiation

1.2: Inert atmosphere; Reflux

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 3 h / 0 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; iodine; lead(IV) tetraacetate; In dichloromethane;
DOI:10.1021/ol301676z