40290-56-0

Basic information

• Product Name: Z-LEU-SER-OME
• Synonyms: CARBOBENZYLOXY-L-LEUCYL-L-SERINE METHYL ESTER;Z-LEU-SER-OME
• CAS NO: 40290-56-0
• Molecular Formula: C₁₈H₂₆N₂O₆
• Molecular Weight: 366.41
• Mol File: 40290-56-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-LEU-SER-OME(CAS DataBase Reference)
• NIST Chemistry Reference: Z-LEU-SER-OME(40290-56-0)
• EPA Substance Registry System: Z-LEU-SER-OME(40290-56-0)

Safety Data

• Hazardous Substances Data: 40290-56-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Z-LEU-SER-OME is used as an anti-inflammatory agent for its capacity to inhibit the activity of enzymes that contribute to the inflammatory process. This makes it a potential therapeutic option for managing conditions characterized by excessive inflammation.
Used in Immunology Research:
In the field of immunology, Z-LEU-SER-OME is utilized as a research tool to study the modulation of immune responses. Its effects on promoting the production of anti-inflammatory molecules can provide insights into the development of treatments for autoimmune diseases where the immune system mistakenly attacks the body's own tissues.
Used in Drug Development:
Z-LEU-SER-OME is employed as a lead compound in drug development for inflammatory disorders. Its potential to regulate immune responses and reduce inflammation without causing significant side effects makes it a valuable asset in creating new therapeutic agents for a range of conditions, including but not limited to rheumatoid arthritis, inflammatory bowel disease, and other autoimmune disorders.

Upstream product

• 2018-66-8 Z-Leu-OH 
• 2788-84-3 (S)-serine methyl ester 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 148854-04-0 (C₈H₇O₂)(NHCHCOO)(CH₂C₃H₇)(CO₂C₂H₅) 
• 3397-35-1 Z-L-leucine hydroxysuccinimide ester 

Downstream Products

• 212612-28-7 Z-Leu-Ser-OH 
• 1384457-99-1 N-(N-benzyloxycarbonyl-L-leucyl)-2-(diethoxyphosphoryl)glycine methyl ester 
• 1384458-02-9 (Z)-N-(N-benzyloxycarbonyl-L-leucyl)-α,β-dehydro-5-(phenyl)norvaline methyl ester 
• 1384458-01-8 N-(N-benzyloxycarbonyl-L-leucyl)-α,β-dehydrovaline methyl ester 
• 1384458-00-7 (Z)-N-(N-benzyloxycarbonyl-L-leucyl)-α,β-dehydroleucine methyl ester 
• 1384457-98-0 N-(N-benzyloxycarbonyl-L-leucyl)-2-(methoxy)glycine methyl ester 
• 155225-21-1 (2R,5S)-2-hydroxymethyl-5-iso-butylpiperazine 

Relevant articles and documents

Tripeptide analogues of MG132 as protease inhibitors

The 26S proteasome and calpain are linked to a number of important human diseases. Here, we report a series of analogues of the prototypical tripeptide aldehyde inhibitor MG132 that show a unique combination of high activity and selectivity for calpains over proteasome. Tripeptide aldehydes (1–3) with an aromatic P3 substituent show enhanced activity and selectivity against ovine calpain 2 relative to chymotrypsin-like activity of proteasome. Docking studies reveal the key contacts between inhibitors and calpain to confirm the importance of the S3 pocket with respect to selectivity between calpains 1 and 2 and the proteasome.

General and versatile approach to the synthesis of optically active 5-alkylpiperazine-2-carboxylic acids

General and convenient syntheses of optically active 5-alkylpiperazine-2-carboxylic acids are described. The methods are based on cyclization of L- or D-serine with α-amino acids and occur without loss of optical purity. The presented procedures are based

Chiral Ligands Containing Heteroatoms. 11. Optically Active 2-Hydroxymethyl Piperazines as Catalyst in the Enantioselective Addition of Diethylzinc to Benzaldehyde

Starting from enantiomerically pure serine, a series of (2R,5S) and (2S,5S)-2-hydroxymethyl-5-alkyl piperazines 1-5 were prepared in good yields without any racemization.The use of these compounds as chiral catalysts for the enantioselective addition of d