4-(4-fluorobenzoyl)-1-(7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl)piperidine

Base Information

Chemical Name:4-(4-fluorobenzoyl)-1-(7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl)piperidine
CAS No.:174469-13-7
Molecular Formula:C₂₀H₂₀ClFN₂O₂
Molecular Weight:374.842
Hs Code.:

Synonyms:4-(4-fluorobenzoyl)-1-(7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl)piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-fluorobenzoyl)-1-(7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl)piperidine

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Technology Process of 4-(4-fluorobenzoyl)-1-(7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl)piperidine

There total 3 articles about 4-(4-fluorobenzoyl)-1-(7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 56346-57-7
(4-fluorophenyl)-piperidin-4-ylmethanone

: 174469-08-0
7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl 4-toluenesulfonate

: 7-chloro-3-methylene-2,3-dihydrofuro<2,3-c>pyridine

: 174469-13-7
4-(4-fluorobenzoyl)-1-(7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl)piperidine

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 60h; Ambient temperature;

Reference yield:

: 152560-63-9
2-chloro-3-(oxiranylmethoxy)-pyridine

: 174469-13-7
4-(4-fluorobenzoyl)-1-(7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / LDA / tetrahydrofuran; heptane / 0.33 h / -78 °C

2: 89 percent / NEt₃ / CH₂Cl₂ / 16 h / Ambient temperature

3: 20 percent / Et₃N / dimethylformamide / 60 h / Ambient temperature

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 174469-04-6
(7-chloro-2,3-dihydrofuro<2,3-c>pyridine-3-yl)methanol

: 174469-13-7
4-(4-fluorobenzoyl)-1-(7-chloro-2,3-dihydrofuro<2,3-c>pyridin-3-ylmethyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / NEt₃ / CH₂Cl₂ / 16 h / Ambient temperature

2: 20 percent / Et₃N / dimethylformamide / 60 h / Ambient temperature

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;