(+/-)-methyl 3-benzoyloxy-4-(2-hydroxybut-3-ynyl)-5-nitrobenzoate

Base Information

Chemical Name:(+/-)-methyl 3-benzoyloxy-4-(2-hydroxybut-3-ynyl)-5-nitrobenzoate
CAS No.:1315454-93-3
Molecular Formula:C₁₉H₁₇NO₆
Molecular Weight:355.347
Hs Code.:

Synonyms:(+/-)-methyl 3-benzoyloxy-4-(2-hydroxybut-3-ynyl)-5-nitrobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-methyl 3-benzoyloxy-4-(2-hydroxybut-3-ynyl)-5-nitrobenzoate

Chemical Property:

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Technology Process of (+/-)-methyl 3-benzoyloxy-4-(2-hydroxybut-3-ynyl)-5-nitrobenzoate

There total 6 articles about (+/-)-methyl 3-benzoyloxy-4-(2-hydroxybut-3-ynyl)-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4301-14-8
acetylenemagnesium bromide

: 704906-34-3
3-benzoyloxy-5-nitro-4-(2-oxoethyl)benzoic acid methyl ester

: 1315454-93-3
(+/-)-methyl 3-benzoyloxy-4-(2-hydroxybut-3-ynyl)-5-nitrobenzoate

Guidance literature:: With magnesium bromide ethyl etherate; In tetrahydrofuran; at 0 - 20 ℃; for 10h; Inert atmosphere;
DOI:10.1002/chem.201003489

Reference yield:

: 16533-71-4
3,5-dinitro-p-toluic acid

: 1315454-93-3
(+/-)-methyl 3-benzoyloxy-4-(2-hydroxybut-3-ynyl)-5-nitrobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diammonium sulfide / ethanol; water / 10.25 h / 80 °C / Inert atmosphere

2.1: sulfuric acid; water; sodium nitrite / 5.5 h / 0 - 90 °C / Inert atmosphere

3.1: sulfuric acid / 26 h / 65 °C / Inert atmosphere

4.1: potassium carbonate / acetone / 3.5 h / 60 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 4 h / 140 °C / Inert atmosphere

5.2: 1 h / 20 °C

6.1: magnesium bromide ethyl etherate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere

With diammonium sulfide; sulfuric acid; water; potassium carbonate; magnesium bromide ethyl etherate; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/chem.201003489

Reference yield:

: 54591-64-9
3-hydroxy-4-methyl-5-nitrobenzoic acid

: 1315454-93-3
(+/-)-methyl 3-benzoyloxy-4-(2-hydroxybut-3-ynyl)-5-nitrobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 26 h / 65 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 3.5 h / 60 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 4 h / 140 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: magnesium bromide ethyl etherate / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere

With sulfuric acid; potassium carbonate; magnesium bromide ethyl etherate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1002/chem.201003489