54591-64-9Relevant academic research and scientific papers
Orally active zwitterionic factor Xa inhibitors with long duration of action
Mochizuki, Akiyoshi,Nagata, Tsutomu,Kanno, Hideyuki,Takano, Daisuke,Kishida, Masamichi,Suzuki, Makoto,Ohta, Toshiharu
, p. 7337 - 7343 (2012/02/04)
We have optimized 2-aminomethylphenylamine derivative as a factor Xa inhibitor. Several polar functional groups were introduced in the central phenyl ring, and we focused on zwitter ionic compound showing continuous inhibitory activity in oral administrat
Development of a flexible strategy towards FR900482 and the mitomycins
Trost, Barry M.,O'Boyle, Brendan M.,Torres, Wildeliz,Ameriks, Michael K.
supporting information; experimental part, p. 7890 - 7903 (2011/08/06)
FR900482 and the mitomycins are two intriguing classes of alkaloid natural products that have analogous biological mechanisms and obvious structural similarity. Both classes possess potent anticancer activity, a feature that has led to their investigation
PROLYL HYDROXYLASE INHIBITORS
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Page/Page column 26-27, (2010/07/10)
The invention described herein relates to certain 2,4-dioxo-l,2,3,4-tetrahydro-7- quinazolinecarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
