N-{[3-fluoro-6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

Base Information

Chemical Name:N-{[3-fluoro-6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine
CAS No.:1187834-70-3
Molecular Formula:C₂₁H₂₁FN₆O
Molecular Weight:392.436
Hs Code.:

Synonyms:N-{[3-fluoro-6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

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Chemical Property of N-{[3-fluoro-6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

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Technology Process of N-{[3-fluoro-6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

There total 5 articles about N-{[3-fluoro-6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1187834-67-8
N-[(6-bromo-3-fluoro-pyridin-2-yl)methoxy]-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

: 693-02-7
hex-1-yne

: 1187834-70-3
N-{[3-fluoro-6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 120 ℃; for 0.05h; Microwave irradiation;

Reference yield:

: 374633-38-2
2-bromo-5-fluoro-6-methyl-2-pyridine

: 1187834-70-3
N-{[3-fluoro-6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2: trifluoroacetic anhydride / 2.5 h / 20 °C / Reflux

3: pyridine; sulfurous dibromide / dichloromethane / 5 - 20 °C

4: caesium carbonate / potassium iodide / acetonitrile / 24 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.05 h / 120 °C / Microwave irradiation

With pyridine; sulfurous dibromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium iodide; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 918793-01-8
(6-bromo-3-fluoropyridin-2-yl)methanol

: 1187834-70-3
N-{[3-fluoro-6-(hex-1-yn-1-yl)pyridin-2-yl]methoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; sulfurous dibromide / dichloromethane / 5 - 20 °C

2: caesium carbonate / potassium iodide / acetonitrile / 24 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.05 h / 120 °C / Microwave irradiation

With pyridine; sulfurous dibromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium iodide; In tetrahydrofuran; dichloromethane; acetonitrile;