4-(2-((4-bromophenyl)thio)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile

Base Information

Chemical Name:4-(2-((4-bromophenyl)thio)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile
CAS No.:1309446-61-4
Molecular Formula:C₂₀H₁₈BrNS₂Si
Molecular Weight:444.491
Hs Code.:

Synonyms:4-(2-((4-bromophenyl)thio)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile

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Chemical Property of 4-(2-((4-bromophenyl)thio)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile

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Technology Process of 4-(2-((4-bromophenyl)thio)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile

There total 4 articles about 4-(2-((4-bromophenyl)thio)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1176869-77-4
4-(2-((4-methoxyphenyl)sulfinyl)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile

: 1213-40-7
S-(4-chlorophenyl)benzene thiosulfonate

: 1309446-61-4
4-(2-((4-bromophenyl)thio)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile

Guidance literature:: 4-(2-((4-methoxyphenyl)sulfinyl)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at -30 ℃; Inert atmosphere;

S-(4-chlorophenyl)benzene thiosulfonate; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1002/chem.201003657

Reference yield:

: 18245-28-8
2-(trimethylsilyl)thiophene

: 1309446-61-4
4-(2-((4-bromophenyl)thio)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0 - 25 °C / Inert atmosphere

1.2: -50 - 25 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

2.3: 2 h / 50 °C / Inert atmosphere

3.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

3.2: 1 h / 25 °C / Inert atmosphere

With n-butyllithium; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1002/chem.201003657

Reference yield:

: 31401-23-7
p-methoxybenzenesulfinyl chloride

: 1309446-61-4
4-(2-((4-bromophenyl)thio)-5-(trimethylsilyl)thiophen-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0 - 25 °C / Inert atmosphere

1.2: -50 - 25 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

2.3: 2 h / 50 °C / Inert atmosphere

3.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

3.2: 1 h / 25 °C / Inert atmosphere

With n-butyllithium; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1002/chem.201003657