5-Fluoroorotic acid monohydrate

Base Information

Chemical Name:5-Fluoroorotic acid monohydrate
CAS No.:220141-70-8
Molecular Formula:C5H3 F N2 O4 . H2 O
Molecular Weight:192.104
Hs Code.:2933599090
European Community (EC) Number:678-852-3
Mol file:220141-70-8.mol

Synonyms:220141-70-8;5-Fluoroorotic acid monohydrate;5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate;5-Fluoroorotic acid hydrate;207291-81-4;5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid;hydrate;5-Fluoroorotic acid, monohydrate;MFCD00150658;C5H5FN2O5;5-Fluorooroticacidhydrate;5-Fluorouracil-6-carboxylic acid monohydrate;5-Fluoro-1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid hydrate;SCHEMBL147605;5-fluoroortic acid monohydrate;5-fluororotic acid monohydrate;5-Fluoroorotic acid hydrate,98;5-fluoro-orotic acid monohydrate;LODRRYMGPWQCTR-UHFFFAOYSA-N;5-Fluoroorotic acid hydrate, 95%;AC7817;5-Fluoroorotic acid hydrate, >=98%;AKOS015893281;DS-2998;PS-8347;SB55567;SB55568;PD017783;SY040026;5-Fluorouracil-4-carboxylic acid monohydrate;5-Fluoroorotic acid hydrate, >=99.0% (TLC);703-95-7(anhydrous) 220141-70-8;A836869;A878810;A918799;J-014424;W-206549;5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate;2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid monohydrate;5-fluoranyl-2,4-bis(oxidanylidene)-1H-pyrimidine-6-carboxylic acid hydrate;2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid, 5-Fluorouracil-4-carboxylic acid;5-Fluoro-2 pound not6-dioxo-1 pound not2 pound not3 pound not6-tetrahydropyrimidine-4-carboxylic acid hydrate

Suppliers and Price of 5-Fluoroorotic acid monohydrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-FluorooroticAcidMonohydrate(UltraPure)
10g
$ 525.00

TRC
5-FluorooroticAcidMonohydrate(UltraPure)
1g
$ 90.00

TCI Chemical
5-Fluoroorotic Acid Monohydrate >95.0%(HPLC)(T)
1g
$ 44.00

TCI Chemical
5-Fluoroorotic Acid Monohydrate >95.0%(HPLC)(T)
100mg
$ 13.00

SynQuest Laboratories
5-Fluoroorotic acid, monohydrate 98%
25 g
$ 165.00

SynQuest Laboratories
5-Fluoroorotic acid, monohydrate 98%
1 g
$ 15.00

SynQuest Laboratories
5-Fluoroorotic acid, monohydrate 98%
5 g
$ 55.00

Matrix Scientific
5-Fluoroorotic acid monohydrate 98%
25g
$ 237.00

Matrix Scientific
5-Fluoroorotic acid monohydrate 98%
1g
$ 17.00

Matrix Scientific
5-Fluoroorotic acid monohydrate 98%
5g
$ 95.00

Total 22 raw suppliers

Chemical Property of 5-Fluoroorotic acid monohydrate

Chemical Property:

Melting Point:278 °C (dec.)(lit.)
Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：112.25000
Density:1.81g/cm³
LogP:-1.16380
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
Solubility.:Aqueous Base (Heated), DMSO (Sparingly, Heated), Methanol (Sparingly), Water (Sl
Water Solubility.:Soluble in water, dimethyl sulfoxide, 50mg in 1ml (1:1 ammonium hydroxide: water) with gentle heating.
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:192.01824943
Heavy Atom Count:13
Complexity:309

Purity/Quality:

97% ^*data from raw suppliers

5-FluorooroticAcidMonohydrate(UltraPure) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1(=C(NC(=O)NC1=O)C(=O)O)F.O
Description 5-fluoro Orotic acid (5-FOA) is used to detect URA3 gene expression in yeast molecular genetic constructs. Yeast with an active URA3 gene, which encodes orotine-5''-monophosphate decarboxylase, converts 5-FOA to fluorodeoxyuridine, which is toxic to cells. Resistant strains of yeast that carry a mutation in the URA3 gene grow in the presence of 5-FOA if the media is supplemented with uracil.
Uses 5-Fluoroorotic Acid, Monohydrate (5-FOA) has become a valuable tool for research in the field of molecular genetics and has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5í-phosphate decarboxylation.

Technology Process of 5-Fluoroorotic acid monohydrate

There total 2 articles about 5-Fluoroorotic acid monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%