(4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester

Base Information

• Chemical Name: (4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester
• CAS No.: 1330763-30-8
• Molecular Formula: C₉H₁₈N₂O₃
• Molecular Weight: 202.254
• Mol file: 1330763-30-8.mol

Synonyms:(4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester

Chemical Property of (4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester

There total 1 articles about (4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

(3S,4S)-tetrahydro-3,4-furandiamine (45434-73-9) + di-tert-butyl dicarbonate (24424-99-5) → (4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester (1330763-30-8,1629586-23-7,335276-55-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; methanol; dichloromethane;

Reference yield: 53.0%

(4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester (1330763-30-8,1629586-23-7,335276-55-6) + 4-[(4-fluorophenyl)methyl]-cyclohexanone (335276-54-5) → tert-butyl (3S,4S)-4-{[4-(4-fluorobenzyl)cyclohexyl]amino}tetrahydro-3-furanylcarbamate (335388-53-9) + tert-butyl carbazate (4248-19-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield: 35.2%

(4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester (1330763-30-8,1629586-23-7,335276-55-6) + 7-chloro-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(3-(dimethylamino)propyl)-1,6-naphthyridine-2(1H)-one → (4-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(3-(dimethylamino)propyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)amino)tetrahydrofuran-3-yl)carbamic acid tert-butyl ester

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 120 ℃; for 4h; Inert atmosphere;

upstream raw materials:

(3S,4S)-tetrahydro-3,4-furandiamine

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl (3S,4S)-4-{[4-(4-fluorobenzyl)cyclohexyl]amino}tetrahydro-3-furanylcarbamate

tert-butyl carbazate