Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

Base Information

Chemical Name:Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate
CAS No.:354118-66-4
Molecular Formula:C₂₈H₃₆N₂O₆
Molecular Weight:496.604
Hs Code.:

Synonyms:Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

Suppliers and Price of Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

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Technology Process of Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

There total 3 articles about Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 205517-34-6
(3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

: 354118-66-4
Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

: 354118-71-1
Ethyl (3R,6S,2'R)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

Guidance literature:: (3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

Ethyl 2-bromopropionate; In tetrahydrofuran; at -78 ℃; for 12h;
DOI:10.1055/s-2001-14596

Reference yield: 93.0%

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 205517-34-6
(3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione

: 30365-54-9
ethyl (S)-2-bromopropionate

: 51063-99-1
(R)-ethyl 2-bromopropanoate

: 354118-66-4
Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

: 354118-71-1
Ethyl (3R,6S,2'R)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.tet.2006.05.033

Reference yield:

: 354118-71-1
Ethyl (3R,6S,2'R)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

: 354118-66-4
Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate

Guidance literature:: With lithium hexamethyldisilazane; methyl iodide; In tetrahydrofuran; ethanol; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2006.05.033