(E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester
CAS No.:343566-33-6
Molecular Formula:C₅₀H₄₈N₄O₇
Molecular Weight:816.954
Hs Code.:

Synonyms:(E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Suppliers and Price of (E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

There total 11 articles about (E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132388-60-4,200625-96-3
(S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid

: 343566-33-6
(E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 4-methylmorpholine / tetrahydrofuran / 20 h / -10 °C

2.1: NaBH₄ / H₂O / 5 h / 23 °C

3.1: 7.6 g / imidazole / dimethylformamide

4.1: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

5.1: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

6.1: i-Pr₂NEt / CH₂Cl₂

7.1: NaH / tetrahydrofuran / 0 °C

7.2: NaH / tetrahydrofuran / Heating

8.1: aq. triethylamine trihydrofluoride / acetonitrile / 23 °C

9.1: Dess-Martin periodinane / CH₂Cl₂ / 23 °C

10.1: tetrahydrofuran / Heating

With 4-methyl-morpholine; 1H-imidazole; sodium tetrahydroborate; triethylamine trihydrofluoride; hydrogen; sodium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: 199006-31-0
(1S)-[1-hydroxymethyl-3-(tritylcarbamoyl)propyl]carbamic acid benzyl ester

: 343566-33-6
(E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 7.6 g / imidazole / dimethylformamide

2.1: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

3.1: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

4.1: i-Pr₂NEt / CH₂Cl₂

5.1: NaH / tetrahydrofuran / 0 °C

5.2: NaH / tetrahydrofuran / Heating

6.1: aq. triethylamine trihydrofluoride / acetonitrile / 23 °C

7.1: Dess-Martin periodinane / CH₂Cl₂ / 23 °C

8.1: tetrahydrofuran / Heating

With 1H-imidazole; triethylamine trihydrofluoride; hydrogen; sodium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: C₃₅H₃₄N₂O₇

: 343566-33-6
(E)-(S)-4-[(S)-2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaBH₄ / H₂O / 5 h / 23 °C

2.1: 7.6 g / imidazole / dimethylformamide

3.1: H₂ / Pd/C / ethanol / 23 °C / 2585.81 Torr

4.1: 4.85 g / i-Pr₂NEt; HATU / dimethylformamide / 1.42 h / 0 - 23 °C

5.1: i-Pr₂NEt / CH₂Cl₂

6.1: NaH / tetrahydrofuran / 0 °C

6.2: NaH / tetrahydrofuran / Heating

7.1: aq. triethylamine trihydrofluoride / acetonitrile / 23 °C

8.1: Dess-Martin periodinane / CH₂Cl₂ / 23 °C

9.1: tetrahydrofuran / Heating

With 1H-imidazole; sodium tetrahydroborate; triethylamine trihydrofluoride; hydrogen; sodium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm010469k