N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethane sulfonamide

Base Information

Chemical Name:N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethane sulfonamide
CAS No.:1344117-77-6
Molecular Formula:C₁₉H₂₂FN₅O₄S₃
Molecular Weight:499.611
Hs Code.:

Synonyms:N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethane sulfonamide

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Chemical Property of N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethane sulfonamide

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Technology Process of N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethane sulfonamide

There total 3 articles about N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethane sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344117-75-4
N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

: 1344117-77-6
N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethane sulfonamide

Guidance literature:: With ammonium molibdate; tetrabutylammomium bromide; dihydrogen peroxide; In dichloromethane; at 0 - 5 ℃; for 10h;

Reference yield:

: 147118-36-3
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

: 1344117-77-6
N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethane sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 5 °C

2.2: pH 3.5

2.3: 20 °C

3.1: ammonium molibdate; tetrabutylammomium bromide; dihydrogen peroxide / dichloromethane / 10 h / 0 - 5 °C

With dmap; ammonium molibdate; tetrabutylammomium bromide; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 1344117-76-5
[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]methyl diphenyl phosphate

: 1344117-77-6
N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfonyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethane sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 5 °C

1.2: pH 3.5

1.3: 20 °C

2.1: ammonium molibdate; tetrabutylammomium bromide; dihydrogen peroxide / dichloromethane / 10 h / 0 - 5 °C

With ammonium molibdate; tetrabutylammomium bromide; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;