N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

Base Information

Chemical Name:N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
CAS No.:1344117-75-4
Molecular Formula:C₁₉H₂₂FN₅O₂S₃
Molecular Weight:467.612
Hs Code.:

Synonyms:N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

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Chemical Property of N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

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Technology Process of N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

There total 2 articles about N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344117-76-5
[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]methyl diphenyl phosphate

: 29490-19-5
2-mercapto-5-methyl-1,3,4-thiadiazole

: 1344117-75-4
N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

Guidance literature:: [4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]methyl diphenyl phosphate; 2-mercapto-5-methyl-1,3,4-thiadiazole; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 5 ℃;

With hydrogenchloride; In dichloromethane; water; pH=3.5;

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃;

Reference yield:

: 147118-36-3
N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

: 1344117-75-4
N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 5 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 5 °C

2.2: pH 3.5

2.3: 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 1344117-75-4
N-[4-(4-fluorophenyl)-5-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

: 289042-12-2,1378943-63-5
2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium molibdate; tetrabutylammomium bromide; dihydrogen peroxide / dichloromethane / 10 h / 0 - 5 °C

2: sodium methylate / tetrahydrofuran / -15 - 10 °C

With ammonium molibdate; tetrabutylammomium bromide; dihydrogen peroxide; sodium methylate; In tetrahydrofuran; dichloromethane;