AKOS B018293

Base Information

• Chemical Name: AKOS B018293
• CAS No.: 350-22-1
• Molecular Formula: C10H6 F N O S2
• Molecular Weight: 239.294
• Hs Code.: 2934999090
• Mol file: 350-22-1.mol

Synonyms:AKOS B018293;ART-CHEM-BB B018293;CHEMBRDG-BB 3018293;(5E)-5-(2-fluorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one

Chemical Property of AKOS B018293

Chemical Property:

• Vapor Pressure: 2.17E-05mmHg at 25°C
• Refractive Index: 1.706
• Boiling Point: 360.7°C at 760 mmHg
• Flash Point: 172°C
• PSA: 93.53000
• Density: 1.5g/cm³
• LogP: 2.16140

Purity/Quality:

98%min ^*data from raw suppliers

(5E)-5-(2-Fluorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS B018293

There total 2 articles about AKOS B018293 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-thioxo-4-thiazolidinone (141-84-4) + 2-Fluorobenzaldehyde (446-52-6) → (5Z)-5-(2-fluorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (350-22-1)

Guidance literature:

With ammonia; ammonium chloride; In ethanol; water; for 2h; diastereoselective reaction; Reflux;

DOI:10.3390/molecules16065207

Reference yield:

2-thioxo-4-thiazolidinone (141-84-4) + 2-Fluorobenzaldehyde (446-52-6) → C10H6FNOS2 (350-22-1)

Guidance literature:

With sodium acetate; In acetic acid; Reflux;

DOI:10.1016/j.carres.2010.04.011

Reference yield: 52.0%

C10H6FNOS2 (350-22-1) + 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-(2-fluorophenylmethylene)-2-thioxo-4-thiazolidinone (1236049-23-2)

Guidance literature:

With potassium hydroxide; In water; acetone; at 20 ℃;

DOI:10.1016/j.carres.2010.04.011

upstream raw materials:

2-thioxo-4-thiazolidinone

2-Fluorobenzaldehyde

Downstream raw materials:

C₁₆H₁₇FN₂O₃S

C₁₉H₁₅FN₂O₃S

(Z)-2-(5-(2-fluorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-4-methyl-N-tosylpentanamide

(Z)-2-(5-(2-fluorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-phenyl-N-tosylpropanamide

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