cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate

Base Information

Chemical Name:cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate
CAS No.:1415573-13-5
Molecular Formula:C₁₄H₂₅NO₃
Molecular Weight:255.357
Hs Code.:

Synonyms:cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate

Suppliers and Price of cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate

There total 10 articles about cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1415573-10-2
cis benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate

: 1415573-13-5
cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; under 1034.32 Torr; diastereoselective reaction;
DOI:10.1016/j.tet.2014.04.064

Reference yield:

: 99183-13-8
methyl 2-(4-hydroxycyclohexyl)acetate

: 1415573-13-5
cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

2.1: hydrogen; acetic acid / Rh/AI₂O₃ / 80 °C / 60006 Torr

3.1: chloro-trimethyl-silane; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / -65 - 0 °C

4.1: ChiralPak AD / ethanol; carbon dioxide / Resolution of racemate

5.1: hydrogen / 5%-palladium/activated carbon / 48 h / 760.05 Torr

With chloro-trimethyl-silane; di-isopropyl azodicarboxylate; hydrogen; acetic acid; triethylamine; triphenylphosphine; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; carbon dioxide;

Reference yield:

: 626-64-2,157061-69-3
pyridin-4-ol

: 1415573-13-5
cis methyl 2-(4-(piperidin-4-yloxy)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

2.1: hydrogen; acetic acid / Rh/AI₂O₃ / 80 °C / 60006 Torr

3.1: chloro-trimethyl-silane; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / -65 - 0 °C

4.1: ChiralPak AD / ethanol; carbon dioxide / Resolution of racemate

5.1: hydrogen / 5%-palladium/activated carbon / 48 h / 760.05 Torr

With chloro-trimethyl-silane; di-isopropyl azodicarboxylate; hydrogen; acetic acid; triethylamine; triphenylphosphine; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; carbon dioxide;