99183-13-8

Usage

Uses

Used in the Cosmetics and Personal Care Products Industry:
(4-Hydroxy-cyclohexyl)-acetic acid methyl ester is used as a fragrance ingredient for its ability to add a sweet, fruity, and floral scent to various products such as perfumes, colognes, and body care items. Its pleasant aroma enhances the sensory experience of these products, making them more appealing to consumers.
Used in the Food Industry:
In the food industry, (4-Hydroxy-cyclohexyl)-acetic acid methyl ester is utilized as a flavoring agent to impart a fruity or floral taste to food products. This contributes to the overall flavor profile and enhances the eating experience for consumers.
Used in Safety Assurance:
(4-Hydroxy-cyclohexyl)-acetic acid methyl ester has been assessed by the Cosmetic Ingredient Review Expert Panel, which has deemed it safe for use in cosmetics and personal care products. This ensures that the ester can be incorporated into formulations without posing health risks to consumers, providing a safe and enjoyable experience.

InChI:InChI=1/C9H16O3/c1-12-9(11)6-7-2-4-8(10)5-3-7/h7-8,10H,2-6H2,1H3

Upstream product

• 14199-15-6 Methyl 4-hydroxyphenylacetate 

Downstream Products

• 99799-09-4 2-(4-hydroxycyclohexyl)acetic acid 
• 1124174-16-8 methyl 2-((1r,4r)-4-hydroxycyclohexyl)acetate 
• 78002-68-3 (hydroxy-4 cyclohexyl)acetate de methyle-cis 
• 66405-41-2 (4-oxo-cyclohexyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS

A compound according to formula I in the form of any one of its stereoisomers or a mixture thereof (l) wherein is indicating a carbon-carbon single or double bond, with the provision that the compound has one carbon-carbon double bond or two isolated or c

NOVEL COMPOUNDS

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

NOVEL COMPOUNDS

Disclosed are novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

A biocatalytic/reductive etherification approach to substituted piperidinyl ethers

A synthetically useful protocol has been developed for the preparation of highly functionalized piperidinyl ethers. Biocatalytic reduction of cyclhexanones 7, 10, and 14 allows for the preparation of both cis- and trans diastereomers with an extremely high degree of stereochemical control. Reductive etherification of the corresponding trimethylsilylethers with 1-(benzyloxycarbonyl)-4-piperidinone 17 in the presence of triethylsilane and catalytic TMSO-Tf provides the desired piperidinyl ethers in good to excellent yields. Finally hygrogenolysis of the nitrogen protecting group leads to piperidinyl ethers in near quantitative yields. Application of the methodology to a range of piperidinyl ethers, including the core scaffolds of diphenylpyraline and ebastine, is also described.

CHEMICAL COMPOUNDS 979

Compounds of formula (I), or pharmaceutically-acceptable salts and/or pro-drugs thereof, which inhibit acetyl CoA(acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, wherein n is 0 to 3; p is 0 or 1; q is 0 to 2; R1and R2are, for example, independently fluoro, chloro, bromo, cyano or (1-4C)alkyl; X is -O-, -S- or -NRa- wherein Ra is hydrogen or (1-4C)alkyl; RA1 and RA2 are, for example, independently hydrogen or (1-4C)alkyl; Ring A is a di-linked ring or ring system chosen from (4-6C)cycloalkane, (7- 10C)bicycloalkane and (8-12C)tricycloalkane each optionally substituted, for example, by one substituent selected from (1-4C)alkyl, (1-4C)alkoxy and (1-4C)alkoxy(1-4C)alkyl; or Ring A is phenylene optionally substituted, for example, by up to four substituents selected from fluoro, chloro, bromo, cyano, (1-4C)alkyl, (1-4C)alkoxy and (1- 4C)alkoxy(1-4C)alkyl; togetherwith processes for their preparation, pharmaceutical compositions containing them and their use as medicaments.