2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester
• CAS No.: 182866-73-5
• Molecular Formula: C₁₈H₂₂N₂O₅
• Molecular Weight: 346.383
• Mol file: 182866-73-5.mol

Synonyms:2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester

Chemical Property of 2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester

There total 9 articles about 2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-butyric acid methyl ester → 2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester (182866-73-5)

Guidance literature:

With Burgess Reagent; In tetrahydrofuran; for 0.0666667h; microwave irradiation;

DOI:10.1055/s-1999-2905

Reference yield: 65.0%

methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-3-oxobutanoate (182866-65-5) → 2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester (182866-73-5)

Guidance literature:

With iodine; triethylamine; triphenylphosphine; In dichloromethane; Ambient temperature;

DOI:10.1039/a704093h

Reference yield: 29.0%

(4S,5S)-2-((1S)-1-benzyloxycarbonylamino-2-methylpropyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester (145587-61-7) → 2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid methyl ester (182866-73-5)

Guidance literature:

With nickel(IV) oxide; In chloroform; for 48h; Heating;

DOI:10.1021/jo00066a004

upstream raw materials:

(4S,5S)-2-((1S)-1-benzyloxycarbonylamino-2-methylpropyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-3-oxobutanoate

2-Diazo-3-oxo-butyric acid methyl ester

(S)-N-benzyloxycarbonylvalinamide

Downstream raw materials:

[(S)-1-(4-Carbamoyl-5-methyl-oxazol-2-yl)-2-methyl-propyl]-carbamic acid benzyl ester

2-{[2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carbonyl]-amino}-3-oxo-butyric acid methyl ester

(1-{4-[2-(1H-indol-3-yl)-ethylcarbamoyl]-5-methyl-oxazol-2-yl}-2-methyl-propyl)-carbamic acid benzyl ester

2-((S)-1-Benzyloxycarbonylamino-2-methyl-propyl)-5-methyl-oxazole-4-carboxylic acid