N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide

Base Information

Chemical Name:N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide
CAS No.:1070777-04-6
Molecular Formula:C₂₄H₃₇N₃O₃
Molecular Weight:415.576
Hs Code.:

Synonyms:N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide

Suppliers and Price of N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide

There total 11 articles about N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: C₃₂H₄₅N₃O₄

: 1070777-04-6
N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide

Guidance literature:: With ammonium cerium (IV) nitrate; In water; acetonitrile; at -10 - 0 ℃; for 14h; Inert atmosphere;
DOI:10.1016/j.tetlet.2016.03.017

Reference yield: 58.0%

: 1067658-74-5
N-(S)-azepan-2-one-3-yl-(S)-2-methylamino-3-phenylpropanamide

: 111-64-8
n-octanoic acid chloride

: 1070777-04-6
N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide

Guidance literature:: With 4-methyl-morpholine; dmap; In N,N-dimethyl-formamide; at 160 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/ol801842v

Reference yield:

: 51987-73-6
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

: 1070777-04-6
N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)octanamide

Guidance literature:: Multi-step reaction with 6 steps

1: silver(l) oxide / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

3: sodium hydrogencarbonate / water; dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4: lithium hydroxide / water; tetrahydrofuran; ethanol / 3 h / 0 - 20 °C / Inert atmosphere

5: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

6: ammonium cerium (IV) nitrate / water; acetonitrile / 14 h / -10 - 0 °C / Inert atmosphere

With 4-methyl-morpholine; ammonium cerium (IV) nitrate; sodium hydrogencarbonate; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; silver(l) oxide; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3: |Schotten-Baumann Reaction;
DOI:10.1016/j.tetlet.2016.03.017