6-(4-dimethylamino-phenyl)-5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Base Information

Chemical Name:6-(4-dimethylamino-phenyl)-5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
CAS No.:124066-02-0
Molecular Formula:C₂₁H₁₉N₃O₂
Molecular Weight:345.401
Hs Code.:

Synonyms:6-(4-dimethylamino-phenyl)-5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

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Chemical Property of 6-(4-dimethylamino-phenyl)-5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

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Technology Process of 6-(4-dimethylamino-phenyl)-5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

There total 3 articles about 6-(4-dimethylamino-phenyl)-5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 97606-30-9
2-(4-methoxyphenyl)-1-(4-dimethylaminophenyl)ethan-1-one

: 107-91-5
cyanoacetic acid amide

: 124066-02-0
6-(4-dimethylamino-phenyl)-5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Guidance literature:: N,N-dimethyl-formamide dimethyl acetal; 2-(4-methoxyphenyl)-1-(4-dimethylaminophenyl)ethan-1-one; In N,N-dimethyl-formamide; at 85 ℃; for 18h;

cyanoacetic acid amide; With sodium methylate; In N,N-dimethyl-formamide; at 95 ℃; for 18h; Further stages.;
DOI:10.1021/jm0110789

Reference yield:

: 55504-32-0
2-(4-(dimethylamino)phenyl)-2-((trimethylsilyl)oxy)acetonitrile

: 124066-02-0
6-(4-dimethylamino-phenyl)-5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 18 h / 20 °C

2.1: 50 g / 1 M aq. H₂SO₄ / methanol / 18 h / 20 °C

3.1: dimethylformamide / 18 h / 85 °C

3.2: 95 percent / NaOMe / dimethylformamide / 18 h / 95 °C

With sulfuric acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0110789

Reference yield:

: 100-10-7
4-dimethylamino-benzaldehyde

: 124066-02-0
6-(4-dimethylamino-phenyl)-5-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: ZnI₂ / CH₂Cl₂ / 6 h / 20 °C

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: tetrahydrofuran / 18 h / 20 °C

3.1: 50 g / 1 M aq. H₂SO₄ / methanol / 18 h / 20 °C

4.1: dimethylformamide / 18 h / 85 °C

4.2: 95 percent / NaOMe / dimethylformamide / 18 h / 95 °C

With sulfuric acid; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0110789